Serena Jain Scott

Interests

Research

Same as above

Teaching

Inpatient Medicine, Geriatric Care, High Value Care, Clinical Operations, Quality Improvement

Courses

Scholarly Contributions

Chapters

• Scott, S., Vemulapalli, T., & Fain, M. (2021). Hospital Medicine. In Geriatrics for Specialists (Textbook). Springer.
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  Scott SJ, Vemulapalli TK, and Fain MJ. Hospital Medicine. (Textbook) Geriatrics for Specialists. Editors: Lee AG, Potter JF and Harper M. Second Edition. Springer 2021
• Pell, J., Rao, D., Thurman, L., & Scott, S. (2016). Procedural Skills for the Hospitalist: Thoracentesis, Paracentesis, Lumbar Puncture, Arthrocentesis. In Hospital Medicine Clinics.

Journals/Publications

• Ripperger, T. J., Uhrlaub, J. L., Watanabe, M., Wong, R., Castaneda, Y., Pizzato, H. A., Thompson, M. R., Bradshaw, C., Weinkauf, C. C., Bime, C., Erickson, H. L., Knox, K., Bixby, B., Parthasarathy, S., Chaudhary, S., Natt, B., Cristan, E., Aini, T. E., Rischard, F., , Campion, J., et al. (2020). Detection, prevalence, and duration of humoral responses to SARS-CoV-2 under conditions of limited population exposure. medRxiv : the preprint server for health sciences.
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  We conducted an extensive serological study to quantify population-level exposure and define correlates of immunity against SARS-CoV-2. We found that relative to mild COVID-19 cases, individuals with severe disease exhibited elevated authentic virus-neutralizing titers and antibody levels against nucleocapsid (N) and the receptor binding domain (RBD) and the S2 region of spike protein. Unlike disease severity, age and sex played lesser roles in serological responses. All cases, including asymptomatic individuals, seroconverted by 2 weeks post-PCR confirmation. RBD- and S2-specific and neutralizing antibody titers remained elevated and stable for at least 2-3 months post-onset, whereas those against N were more variable with rapid declines in many samples. Testing of 5882 self-recruited members of the local community demonstrated that 1.24% of individuals showed antibody reactivity to RBD. However, 18% (13/73) of these putative seropositive samples failed to neutralize authentic SARS-CoV-2 virus. Each of the neutralizing, but only 1 of the non-neutralizing samples, also displayed potent reactivity to S2. Thus, inclusion of multiple independent assays markedly improved the accuracy of antibody tests in low seroprevalence communities and revealed differences in antibody kinetics depending on the viral antigen. In contrast to other reports, we conclude that immunity is durable for at least several months after SARS-CoV-2 infection.
• Scott, S. (2017). Elder Care Sheets. POGOe.
• Scott, S. J. (2017). Transitioning to Scheduling Software?: A Guide for Hospital Medicine Groups.. The Hospitalist.
• Korb, P., Scott, S., Virapongse, A., & Simpson, J. (2016). Coding and Billing Issues in Hospital Neurology Compensation. Neurology: Clinical Practice.
• Jones, C. D., Scott, S. J., Anoff, D. L., Pierce, R. G., & Glasheen, J. J. (2015). Changes in Payer Mix and Physician Reimbursement After the Affordable Care Act and Medicaid Expansion. Inquiry : a journal of medical care organization, provision and financing, 52.
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  Although uncompensated care for hospital-based care has fallen dramatically since the implementation of the Affordable Care Act and Medicaid expansion, the changes in hospital physician reimbursement are not known. We evaluated if payer mix and physician reimbursement by encounter changed between 2013 and 2014 in an academic hospitalist practice in a Medicaid expansion state. This was a retrospective cohort study of all general medicine inpatient admissions to an academic hospitalist group in 2013 and 2014. The proportion of encounters by payer and reimbursement/inpatient encounter were compared in 2013 versus 2014. A sensitivity analysis determined the relative contribution of different factors to the change in reimbursement/encounter. Among 37 540 and 40 397 general medicine inpatient encounters in 2013 and 2014, respectively, Medicaid encounters increased (17.3% to 30.0%, P < .001), uninsured encounters decreased (18.4% to 6.3%, P < 0.001), and private payer encounters also decreased (14.1% to 13.3%, P = .001). The median reimbursement/encounter increased 4.2% from $79.98/encounter in 2013 to $83.36/encounter in 2014 (P < .001). In a sensitivity analysis, changes in length of stay, proportions in encounter type by payer, payer mix, and reimbursement for encounter type by payer accounted for -0.7%, 0.8%, 2.0%, and 2.3% of the reimbursement change, respectively. From 2013 to 2014, Medicaid encounters increased, and uninsured and private payer encounters decreased within our hospitalist practice. Reimbursement/encounter also increased, much of which could be attributed to a change in payer mix. Further analyses of physician reimbursement in Medicaid expansion and non-expansion states would further delineate reimbursement changes that are directly attributable to Medicaid expansion.
• Weiskopf, J., & Scott, S. (2015). Asymptomatic bacteriuria, what are you treating?. JAMA internal medicine, 175(3), 344-5.

Presentations

• Scott, S., Ellis, S. C., Meinke, L. E., & Mikhael, D. M. (2019, May). Innovations Quickfire: Residents as Teachers. Graduate Medical Education (GME). Tucson, AZ.

Reviews

• Parker, K., Nikolich, J. Z., Partha, I., Lieberman, D., Fain, M. J., Scott, S., Phillips, L. R., Russell, S., & Cegledi, A. (2024. Post-Acute Sequelae of SARS-CoV-2 Infection (Long COVID) in Older Adults.
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  Invited review article in preparation for publication 2024
• Parker, K., Parker, K., Nikolich, J. Z., Nikolich, J. Z., Partha, I., Partha, I., Lieberman, D., Lieberman, D., Fain, M. J., Fain, M. J., Scott, S., Scott, S., Phillips, L. R., Phillips, L. R., Russell, S., Russell, S., Cegledi, A., & Cegledi, A. (2024. Post-Acute Sequelae of SARS-CoV-2 Infection (Long COVID) in Older Adults(pp Dec;46(6):6563-6581). Geroscience.
  More info

  Russell SJ, Parker K, Lehoczki A, Lieberman D, Partha IS, Scott SJ, Phillips LR, Fain MJ, Nikolich JŽ. Post-acute sequelae of SARS-CoV-2 infection (Long COVID) in older adults. Geroscience. 2024 Dec;46(6):6563-6581. doi: 10.1007/s11357-024-01227-8. Epub 2024 Jun 14. PMID: 38874693; PMCID: PMC11493926.Invited review -- first 2 authors shared lead authorship